The presence of so many lithopone factories in China has also led to advancements in production technology and quality control. Chinese manufacturers have invested heavily in research and development to improve the performance of their lithopone products, leading to higher quality and more consistent products on the market. This has helped to cement China's reputation as a leading producer of lithopone on the global stage.

Numerous studies have linked titanium dioxide to genotoxicity and cytotoxicity. Genotoxicity refers to a chemical’s potential to cause DNA damage, which can, in turn, lead to cancer. Cytotoxicity is a general term that refers to a characteristic of being harmful to cells.  

In order to evaluate the penetration of the nanoparticles, eight adult male Wistar rats (3 months old) were used for the in vivo experiments. The protocol was approved by the local University Committee for animal testing and is in accordance with the Canadian Council on Animal Care (CICUAL-RD-2021–892-E-UNC-DEC#FCQ).

Here, NaOH or NH3 · H2O is used as a precipitant or pH regulator to react with FeSO4 to form ferrous hydroxide precipitation; Air is used as oxidant; The iron sheet reacts with sulfuric acid produced during the oxidative hydrolysis of FeSO4 to provide ferrous ions required in the reaction system and maintain the pH value of the solution. The alkali consumption of acid method is less and the particles are easy to wash. The relative rates of seed preparation and crystal growth determine the particle size, particle size distribution and particle morphology of iron yellow particles.

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